Why the study?
Do isolated subcutaneous resistance arteries from patients with essential hypertension have altered elastic characteristics or pharmacological responses compared to normotensive controls?
Population
16 patients with never-treated essential hypertension and 16 normotensive controls matched for age and sex
Comparison
Ex vivo testing of isolated subcutaneous… vs Vessels from normotensive controls matched for…
Design
Case-control
Authors
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Wall elasticity changes do not explain resistance artery remodeling in hypertension; hypothesis-generating for calcium handling abnormalities.
Do isolated subcutaneous resistance arteries from patients with essential hypertension have altered elastic characteristics or pharmacological responses compared to normotensive controls?
The altered morphology of subcutaneous resistance arteries in essential hypertension is not caused by changes in wall elasticity, though abnormal calcium handling may be present.
Thybo et al. (1996) studied this question.
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