Key result
Nitrendipine caused a significantly greater decrease in the elastic modulus of the brachial artery compared to medroxalol and isosorbide dinitrate in men with essential hypertension.
Why the study?
Does nitrendipine reduce the elastic modulus of the brachial artery more than medroxalol or isosorbide dinitrate in men with essential hypertension?
Population
Men with sustained essential hypertension
Comparison
Nitrendipine (calcium entry blocking agent) vs Medroxalol or isosorbide dinitrate
Design
Cohort
Authors
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Hypothesis-generating for preferential arterial compliance effects with nitrendipine; leaves open randomized confirmation and outcome relevance.
Does nitrendipine reduce the elastic modulus of the brachial artery more than medroxalol or isosorbide dinitrate in men with essential hypertension?
Calcium channel blockade with nitrendipine causes a greater decrease in brachial artery elastic modulus compared to autonomic blockade or nitrates in men with essential hypertension.
Safar et al. (1986) studied Essential hypertension. Nitrendipine vs. Medroxalol and isosorbid dinitrate was evaluated on Decrease in Eh product (elastic modulus and wall thickness) after vasodilatation. Nitrendipine caused a significantly greater decrease in the elastic modulus of the brachial artery compared to medroxalol and isosorbide dinitrate in men with essential hypertension.
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