What question did this study set out to answer?

To determine whether increased calcium-influx-mediated vasoconstriction serves as a primary pathogenetic mechanism in essential hypertension.

February 1, 1985British Journal of Clinical PharmacologyOpen Access

Vasodilatory effect of nicardipine and verapamil in the forearm of hypertensive as compared with normotensive man.

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Why the study?

Does intra-arterial infusion of calcium-influx inhibitors (nicardipine and verapamil) reduce forearm vascular resistance more in patients with essential hypertension compared to normotensive subjects?

Population

33 subjects, including 10 normotensive subjects and 23 patients with essential hypertension.

Comparison

Infusion into the brachial artery of sodium… vs Basal conditions and reperfusion following 10…

Design

Cross-sectional

Authors

UHU. Lennart HulthénLund University PBPeter BolliGeneral / Preventive / Lipids BFBühler FrRoche (Switzerland)

Discussion

Member takes

Implication

Suggests calcium influx contributes to moderate hypertension pathogenesis; hypothesis-generating and should not yet alter practice.

Key Points

To determine whether increased calcium-influx-mediated vasoconstriction serves as a primary pathogenetic mechanism in essential hypertension.
Evaluated 10 normotensive control subjects alongside 23 patients with essential hypertension (12 mild, 11 moderate).
Measured forearm blood flow, intra-arterial blood pressure, and vascular resistance under basal conditions, after 10 minutes of arterial occlusion, and during brachial artery infusions of sodium nitroprusside, nicardipine, and verapamil.
Forearm vascular resistance following 10 minutes of arterial occlusion was lowest in normotensive subjects, intermediate in mild hypertension, and highest in moderate hypertension.
Adjusted vasodilator responses to nicardipine and verapamil were significantly greater in patients with moderate essential hypertension than in normotensive controls and patients with mild hypertension.
Adjusted vasodilator responses to sodium nitroprusside did not differ across the normotensive, mild hypertensive, and moderate hypertensive groups.

Structured PICO

Population

33 subjects, including 10 normotensive subjects (mean age 45 +/- 12 years) and 23 patients with essential hypertension (12 with mild EH, mean age 42 +/- 12 years; 11 with moderate EH, mean age 49 +/- 11 years).

Intervention

Infusion into the brachial artery of sodium nitroprusside (0.15 and 0.6 microgram min-1 100 ml-1 tissue for 2 min each), nicardipine (5 and 40 micrograms min-1 100 ml-1 tissue for 1 min each), and verapamil (80 micrograms min-1 100 ml-1 tissue for 1 min).

Comparator

Basal conditions and reperfusion following 10 min arterial occlusion; comparison across normotensive, mild hypertensive, and moderate hypertensive groups.

Outcome

Forearm vascular resistance (FVR)surrogate

Increased calcium-influx-mediated vasoconstriction may be a primary pathogenetic disturbance in moderate essential hypertension, as evidenced by an enhanced vasodilatory response to calcium channel blockers.

Cite This Study

Hulthén et al. (1985) studied this question.

synapsesocial.com/papers/6a88f9eb4f37e970fb7b3eb6 https://doi.org/10.1111/j.1365-2125.1985.tb05144.x

Topics

Hypertension management

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Vasodilatory effect of nicardipine and verapamil in the forearm of hypertensive as compared with normotensive man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Vasodilatory effect of nicardipine and verapamil in the forearm of hypertensive as compared with normotensive man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider