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January 1, 1990Journal of Cardiovascular Pharmacology

Calcium Entry Blockade and Agonist-Mediated Vasoconstriction in Hypertensive Patients

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Why the study?

Does nicardipine compared to verapamil antagonize agonist-mediated vasoconstriction in uncomplicated hypertensive patients?

Population

Uncomplicated hypertensive patients

Comparison

Nicardipine infused into the brachial artery vs Verapamil infused into the brachial artery

Design

Other

Authors

RPRoberto PedrinelliGeneral / Preventive / LipidsSTS. TaddeiGeneral / Preventive / LipidsGPGiovanni PanaraceUniversity of Pisa

Discussion

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Implication

Supports CCB subclass differences on agonist vasoconstriction in hypertension; challenges uniform class effects and warrants prospective confirmation.

Structured PICO

Does nicardipine compared to verapamil antagonize agonist-mediated vasoconstriction in uncomplicated hypertensive patients?

P
Population
Uncomplicated hypertensive patients
I
Intervention
Nicardipine infused into the brachial artery (1 μg/100 ml forearm tissue/min)
C
Comparator
Verapamil infused into the brachial artery (1 μg/100 ml tissue/min)
O
Outcome
Vascular responses (forearm blood flow) to exogenous norepinephrine, lower body negative pressure, and angiotensin II measured using strain gauge venous plethysmographysurrogate

Nicardipine, unlike verapamil, antagonizes agonist-mediated vasoconstriction in hypertensive patients, highlighting pharmacological heterogeneity among calcium channel blockers.

Cite This Study

Pedrinelli et al. (1990) studied this question.

synapsesocial.com/papers/6a80c829d6e5d64541933dbahttps://doi.org/10.1097/00005344-199006162-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium Entry Blockade and Agonist-Mediated Vasoconstriction in Hypertensive Patients1990 · 8 citations
  2. 2Calcium entry blockade and α-adrenergic vascular reactivity in human beings: Differences between nicardipine and verapamil1989 · 16 citations
  3. 3Calcium entry blockade and adrenergic vascular reactivity in hypertensives: Differences between nicardipine and diltiazem1991 · 9 citations
  4. 4Comparison of Cardiovascular, Renal, and Humoral Effects of Acute Administration of Two Calcium Channel Blockers in Normotensive and Hypertensive Subjects1982 · 161 citations
  5. 5The interference by nicardipine and diltiazem on α-adrenergic receptor–mediated vasoconstriction in isolated human subcutaneous arterioles1993 · 3 citations