Why the study?
Do calcium channel blockers improve central hemodynamics by reducing total peripheral resistance without depressing cardiac pump function in patients with essential hypertension?
Population
54 patients aged 20-64 years with mild to moderate essential hypertension
Comparison
Calcium channel blockers for 1 year: verapamil… vs Pretreatment baseline values and placebo tablets
Design
Cohort
Follow-up
1 year
Authors
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May support calcium antagonists in hypertension without reducing cardiac index; leaves open randomized outcome confirmation.
Do calcium channel blockers improve central hemodynamics by reducing total peripheral resistance without depressing cardiac pump function in patients with essential hypertension?
Calcium channel blockers effectively lower blood pressure and peripheral resistance in essential hypertension without compromising cardiac output at rest or during exercise.
Lund‐Johansen et al. (1987) studied this question.
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