Why the study?
Does nifedipine-GITS compared to verapamil-SR improve hemodynamics and left ventricular mass in patients with moderate to severe hypertension?
Population
30 patients with moderate to severe hypertension (pretreatment diastolic blood pressures >= 100 mm Hg)
Comparison
Nifedipine-GITS, dose titrated over 4 weeks to… vs Verapamil-SR, dose titrated over 4 weeks to…
Design
RCT, randomly assigned
Follow-up
6 months
Authors
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Both agents equally reduce BP and LV mass in moderate-severe hypertension; confirms similar target-organ efficacy despite class-specific HR effects.
Does nifedipine-GITS compared to verapamil-SR improve hemodynamics and left ventricular mass in patients with moderate to severe hypertension?
Nifedipine-GITS and verapamil-SR are equally effective for reducing arterial pressure and left ventricular mass in moderate to severe hypertension, with differences in hemodynamic and neurohormonal profiles consistent with their pharmacologic classes.
Joseph A. Diamond (2001) studied this question.
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