Key result
Amlodipine and nifedipine GITS effectively lowered blood pressure with minimal heart rate effects (<1 beat/min), though amlodipine showed greater increases in plasma norepinephrine concentrations.
Why the study?
Do long-acting dihydropyridine calcium-channel blockers (amlodipine vs nifedipine GITS) differentially affect sympathetic nervous system activity in hypertensive patients?
Population
Hypertensive patients
Comparison
Amlodipine or nifedipine GITS vs Compared to each other
Design
Systematic_review
Authors
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Negligible heart rate effects support either agent clinically; extends comparative data on sympathetic responses in hypertension.
Systematic Review
Do long-acting dihydropyridine calcium-channel blockers (amlodipine vs nifedipine GITS) differentially affect sympathetic nervous system activity in hypertensive patients?
Amlodipine and nifedipine GITS both effectively lower blood pressure with minimal heart rate effects, though amlodipine may cause slightly greater sympathetic nervous system activation.
Toal et al. (2012) conducted a systematic review in Hypertension. Amlodipine vs. Nifedipine GITS was evaluated on Sympathetic nervous system activity (plasma norepinephrine concentrations). Amlodipine and nifedipine GITS effectively lowered blood pressure with minimal heart rate effects (<1 beat/min), though amlodipine showed greater increases in plasma norepinephrine concentrations.
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