January 1, 2003Current Medical Research and Opinion

Treatment of mild-to-moderate hypertension with calcium channel blockers: a multicentre comparison of once-daily nifedipine GITS with once-daily amlodipine

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Why the study?

Does nifedipine GITS reduce diastolic blood pressure comparably to amlodipine in patients with mild-to-moderate essential hypertension?

Population

155 patients with mild-to-moderate essential hypertension across 9 university hospitals in Turkey.

Comparison

Nifedipine GITS 30 mg once daily for 12 weeks. vs Amlodipine 5 mg once daily for 12 weeks.

Design

RCT, Randomised, open comparison

Follow-up

12 weeks

Authors

SKSırrı KesHacettepe University Hospital NÇNail ÇağlarKyushu University ACA. CanberkIstanbul University

Discussion

Member takes

Implication

Nifedipine GITS offers a comparable option to amlodipine for mild-to-moderate hypertension; confirms similar efficacy in this RCT.

Structured PICO

Does nifedipine GITS reduce diastolic blood pressure comparably to amlodipine in patients with mild-to-moderate essential hypertension?

Population

155 patients with mild-to-moderate essential hypertension (diastolic blood pressure 95-109 mmHg) across 9 university hospitals in Turkey.

Intervention

Nifedipine GITS 30 mg once daily (titrated to 60 mg once daily if blood pressure not below 140/90 mmHg or diastolic reduction <10 mmHg after 6 weeks) for 12 weeks.

Comparator

Amlodipine 5 mg once daily (titrated to 10 mg once daily if blood pressure not below 140/90 mmHg or diastolic reduction <10 mmHg after 6 weeks) for 12 weeks.

Outcome

Diastolic blood pressure at trough after 12 weeks of active compound therapy adjusted to baseline.surrogate

Once-daily nifedipine GITS and amlodipine are comparably effective and safe for lowering blood pressure in patients with mild-to-moderate essential hypertension.

Cite This Study

Kes et al. (2003) studied this question.

synapsesocial.com/papers/6a715545c92390ac2d07f01f https://doi.org/10.1185/030079903125001677

Topics

Hypertension management

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Treatment of mild-to-moderate hypertension with calcium channel blockers: a multicentre comparison of once-daily nifedipine GITS with once-daily amlodipine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Treatment of mild-to-moderate hypertension with calcium channel blockers: a multicentre comparison of once-daily nifedipine GITS with once-daily amlodipine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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