Why the study?
Does amlodipine maintain better antihypertensive efficacy than nifedipine GITS following missed doses in patients requiring antihypertensive therapy?
Population
42 patients requiring antihypertensive therapy
Comparison
Amlodipine 5-10 mg once daily for 12 weeks vs Nifedipine gastrointestinal therapeutic system…
Design
RCT, randomized crossover design, double-blind
Follow-up
12 weeks per treatment period
Authors
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Amlodipine better preserves DBP control after missed doses; supports preferential use over nifedipine GITS in patients with adherence challenges.
Does amlodipine maintain better antihypertensive efficacy than nifedipine GITS following missed doses in patients requiring antihypertensive therapy?
Amlodipine maintains better blood pressure control than nifedipine GITS during short periods of medication non-compliance.
Elliott et al. (2002) studied this question.
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