Why the study?
Does amlodipine compared to nifedipine GITS improve sustained blood pressure control after missing two doses in patients with hypertension?
Population
58 patients with hypertension
Comparison
Amlodipine 5 mg daily for 4 weeks, followed by 2… vs Nifedipine GITS 30 mg daily for 4 weeks…
Design
RCT, randomly allocated, double-blind, double dummy
Follow-up
4 weeks plus 72 hours
Authors
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Favors amlodipine over nifedipine GITS for variable adherence; extends RCT evidence on CCB forgiveness in hypertension.
Does amlodipine compared to nifedipine GITS improve sustained blood pressure control after missing two doses in patients with hypertension?
Amlodipine provides more sustained blood pressure control than nifedipine GITS in the event of missed doses, maintaining significant antihypertensive effects up to 72 hours.
Hernández et al. (2001) studied this question.
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