Why the study?
Does nifedipine GITS improve quality of life and blood pressure compared to amlodipine in patients with mild to moderate hypertension?
Population
356 randomized patients with mild to moderate hypertension across 13 medical clinics in Spain.
Comparison
Nifedipine gastrointestinal therapeutic system… vs Amlodipine 5 mg once daily for 24 weeks…
Design
RCT, Randomized, Double-blind, double-dummy
Follow-up
24 weeks
Authors
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May favor nifedipine GITS selection when QoL is prioritized; extends head-to-head CCB evidence in hypertension.
Does nifedipine GITS improve quality of life and blood pressure compared to amlodipine in patients with mild to moderate hypertension?
Nifedipine GITS and amlodipine provide similar blood pressure reduction, but nifedipine GITS may offer a more beneficial profile for overall quality of life, while amlodipine may have positive effects on cognitive functioning.
Testa et al. (1998) studied this question.
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