Why the study?
Do intravenous calcium channel blockers (tiapamil, nisoldipine, nifedipine) reduce blood pressure and alter regulatory factors in normal and hypertensive subjects?
Population
20 subjects (10 normal subjects and 10 patients with essential hypertension)
Comparison
Intravenous injection of tiapamil 1 mg/kg body… vs Intravenous injection of placebo (20 ml 0.9% NaCl)
Design
Other, Latin square design
Follow-up
up to 4 or 5 hours
Authors
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Acute IV CCBs may preferentially lower BP and promote natriuresis in hypertensives; leaves open translation to chronic oral use.
Do intravenous calcium channel blockers (tiapamil, nisoldipine, nifedipine) reduce blood pressure and alter regulatory factors in normal and hypertensive subjects?
Intravenous tiapamil, nisoldipine, and nifedipine acutely lower blood pressure and increase sodium excretion in hypertensive patients, with varying effects on sympathetic activity.
Laederach et al. (1986) studied this question.
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