Why the study?
Does nisoldipine affect the renin-angiotensin-aldosterone system and catecholamines in normotensive and hypertensive subjects?
Population
10 healthy volunteers and 29 patients with primary essential hypertension. Eight healthy volunteers received…
Comparison
Nisoldipine vs Placebo (administered to 8 healthy volunteers)
Design
Cohort
Follow-up
up to 6 months
Authors
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Reassures on long-term neurohormonal profile with nisoldipine in hypertension; leaves open effects on outcomes in randomized trials.
Does nisoldipine affect the renin-angiotensin-aldosterone system and catecholamines in normotensive and hypertensive subjects?
Nisoldipine does not cause long-term activation of the renin-angiotensin-aldosterone system or sympathetic nervous system in hypertensive patients.
Ottosson et al. (1990) studied this question.
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