Key result
A single 10 mg oral dose of nisoldipine significantly reduced ST segment depression at peak exercise from 0.21 mV to 0.10 mV (p<0.01) in patients with stable angina pectoris.
Why the study?
Does single oral administration of 10 mg nisoldipine improve exercise-induced hemodynamic changes and ST segment depression in patients with stable angina pectoris?
Population
10 patients with stable effort angina pectoris, mean age 57.6 years, 9 male and 1 female, including 3 with…
Comparison
Single oral administration of 10 mg nisoldipine. vs Baseline (before nisoldipine administration).
Design
Other
Follow-up
1.5 hours post-dose
Authors
Loading...
May reduce acute exercise ischemia in stable angina; leaves open need for RCTs on chronic use and outcomes.
Does single oral administration of 10 mg nisoldipine improve exercise-induced hemodynamic changes and ST segment depression in patients with stable angina pectoris?
Absolute Event Rate: 0.1% vs 0.21%
p-value: p=<0.01
A single 10 mg oral dose of nisoldipine effectively reduces exercise-induced ST depression and improves hemodynamics by lowering systemic vascular resistance in patients with stable angina.
Kamihara et al. (1988) studied Stable angina pectoris (n=10). Nisoldipine vs. Baseline (before administration) was evaluated on ST segment depression at peak exercise (mV) (p=<0.01). A single 10 mg oral dose of nisoldipine significantly reduced ST segment depression at peak exercise from 0.21 mV to 0.10 mV (p<0.01) in patients with stable angina pectoris.