Why the study?
Does nisoldipine administered twice daily improve exercise tolerance and reduce anginal attacks in patients with stable angina pectoris?
Population
185 patients with stable angina pectoris who reproducibly stopped treadmill exercise because of angina of…
Comparison
Nisoldipine 2.5 mg, 5 mg, or 10 mg administered… vs Placebo administered twice daily for 4 weeks.
Design
RCT, Randomized in a double-blind manner to one of the four treatment groups…
Follow-up
4 weeks
Authors
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Nisoldipine twice daily is ineffective for stable angina; does not support use and signals safety concerns at 10 mg BID.
Does nisoldipine administered twice daily improve exercise tolerance and reduce anginal attacks in patients with stable angina pectoris?
Nisoldipine monotherapy twice daily was not superior to placebo for stable angina, and the 10-mg twice-daily dose was associated with a clinically important increase in serious adverse events including sudden death.
Thadani et al. (1991) studied this question.
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