Key result
Addition of nisoldipine or nifedipine to atenolol improved exercise capacity at 2 hours post-dosing (e.g., time to angina +67s for nisoldipine, P<0.01), but the effect was not maintained at 12 hours.
Why the study?
Does the addition of nisoldipine or nifedipine to atenolol improve exercise capacity and reduce ischemia in patients with chronic stable angina pectoris?
Population
24 patients with chronic stable angina pectoris
Comparison
Nisoldipine 10 mg twice daily or slow-release… vs Placebo added to atenolol monotherapy
Design
RCT, double-blind
Follow-up
12 hours post-dosing
Authors
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May require more frequent dosing than twice daily for sustained benefit; confirms short duration of dihydropyridine action on atenolol.
RCT (n=24)
Double-blind
Does the addition of nisoldipine or nifedipine to atenolol improve exercise capacity and reduce ischemia in patients with chronic stable angina pectoris?
p-value: p=< 0.01
The addition of nisoldipine 10 mg or nifedipine 20 mg twice daily to atenolol provides anti-ischemic benefits for less than 12 hours, suggesting more frequent dosing may be needed.
Donaldson et al. (1993) conducted an RCT in chronic stable angina pectoris (n=24). Nisoldipine or nifedipine added to atenolol vs. Atenolol monotherapy (placebo) was evaluated on Exercise capacity 2 hours post-dosing (p=< 0.01). Addition of nisoldipine or nifedipine to atenolol improved exercise capacity at 2 hours post-dosing (e.g., time to angina +67s for nisoldipine, P<0.01), but the effect was not maintained at 12 hours.
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