July 1, 1993Clinical Pharmacology & Therapeutics

The interference by nicardipine and diltiazem on α-adrenergic receptor–mediated vasoconstriction in isolated human subcutaneous arterioles

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Population

Isolated human subcutaneous arterioles

Design

Preclinical

Authors

MSMarzia SpessotVita-Salute San Raffaele University RPRoberto PedrinelliGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May guide CCB choice in vasospastic disorders; leaves open clinical translation from this animal model.

Structured PICO

Population

Isolated human subcutaneous arterioles

Intervention

Nicardipine and diltiazem

Outcome

Percentage of decrement in tension produced by nicardipine or diltiazem after stimulation with norepinephrine at 50% of maximal contractionsurrogate

Nicardipine and diltiazem exert equipotent alpha-adrenolytic effects in isolated human subcutaneous arterioles, highlighting the role of regional vessel characteristics in calcium channel blocker interactions.

Cite This Study

Spessot et al. (1993) studied this question.

synapsesocial.com/papers/6a87357fcbc6304817beff83 https://doi.org/10.1038/clpt.1993.113

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The interference by nicardipine and diltiazem on α-adrenergic receptor–mediated vasoconstriction in isolated human subcutaneous arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The interference by nicardipine and diltiazem on α-adrenergic receptor–mediated vasoconstriction in isolated human subcutaneous arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider