Key result
Infusion of calcium to increase local plasma concentration by ~0.5 mmol/l reduced the dilator response to verapamil by 35% (P<0.02) in normal subjects.
Why the study?
Does a small increase in local plasma calcium concentration alter the responsiveness of forearm resistance vessels to verapamil in normal subjects?
Population
Normal subjects (n=8)
Comparison
Infusion of calcium into the brachial artery vs Initial control state, sodium nitroprusside…
Design
Other
Follow-up
46 minutes (duration of infusion)
Authors
Loading...
Local calcium elevation may blunt verapamil vasodilation; hypothesis-generating for interactions in hypercalcemic patients.
Does a small increase in local plasma calcium concentration alter the responsiveness of forearm resistance vessels to verapamil in normal subjects?
Effect estimate: 35% reduction
p-value: p=<0.02
Small elevations in plasma calcium selectively depress the dilator response to verapamil in forearm resistance vessels, suggesting a role for calcium in regulating membrane function and potentially contributing to primary hypertension.
Robinson et al. (1984) studied Normal subjects (n=8). Calcium infusion vs. Baseline was evaluated on Dilator response to verapamil (35% reduction, p=<0.02). Infusion of calcium to increase local plasma concentration by ~0.5 mmol/l reduced the dilator response to verapamil by 35% (P<0.02) in normal subjects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: