Key result
Calcium infusion at 7.5 mg/kg per hour significantly raised blood pressure and vascular resistance in both normotensive and hypertensive subjects, an effect that was inhibited by verapamil.
Why the study?
Does acute calcium infusion increase blood pressure and vascular resistance in normotensive and hypertensive subjects, and is this effect inhibited by verapamil?
Population
32 subjects (20 normotensive, 12 hypertensive), aged 43-83 years.
Comparison
Acute hypercalcemia induced by calcium infusion… vs Baseline measurements prior to infusion, and…
Design
Other
Follow-up
1 hour
Authors
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Suggests caution with acute calcium administration in hypertension; leaves open relevance to supplementation or vascular targeting.
Does acute calcium infusion increase blood pressure and vascular resistance in normotensive and hypertensive subjects, and is this effect inhibited by verapamil?
Acute calcium infusion raises blood pressure by increasing peripheral vascular resistance, an effect that is more pronounced in absolute terms in hypertensive patients and is reversible with calcium channel blockade.
Suzuki et al. (1988) studied Normotension and hypertension (n=32). Calcium infusion vs. Baseline and verapamil co-infusion was evaluated on Blood pressure and total peripheral vascular resistance. Calcium infusion at 7.5 mg/kg per hour significantly raised blood pressure and vascular resistance in both normotensive and hypertensive subjects, an effect that was inhibited by verapamil.
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