Brachial Artery Elastic Mechanics in Patients With Heart Failure
Why the study?
Does sublingual nitroglycerin alter brachial arterial wall mechanics in patients with heart failure compared to normal subjects?
Population
19 patients with New York Heart Association class II to IV heart failure and 17 age- and size-matched normal…
Comparison
0.4 mg sublingual nitroglycerin (NTG) vs Baseline measurements and normal subjects
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Preserved NTG responsiveness in HF arteries despite remodeling; hypothesis-generating and should not yet change practice.
Structured PICO
Does sublingual nitroglycerin alter brachial arterial wall mechanics in patients with heart failure compared to normal subjects?
P
Population
19 patients with New York Heart Association class II to IV heart failure and 17 age- and size-matched normal subjects (total n=36)
I
Intervention
0.4 mg sublingual nitroglycerin (NTG)
C
Comparator
Baseline measurements (pre-NTG) and normal subjects
O
Outcome
Brachial arterial wall mechanics (area, compliance, pulse wave velocity, incremental elastic modulus, wall-to-lumen ratio) measured by ultrasound wall-tracking system and tonometrysurrogate
Patients with heart failure have an increased brachial arterial wall-to-lumen ratio but preserved overall mechanical behavior, and their arterial smooth muscle responds normally to nitroglycerin.
Cite This Study
Kaiser et al. (2001) studied this question.