Key result
Isolated hypertension is associated with decreased AVP and FMD and increased CIMT compared to healthy controls, with AVP and CIMT showing a significant inverse correlation (r=-0.699, P<0.001).
Why the study?
Does isolated hypertension affect noninvasive markers of atherosclerosis such as CIMT, FMD, and AVP compared to healthy controls?
Case-Control (n=90)
Does isolated hypertension affect noninvasive markers of atherosclerosis such as CIMT, FMD, and AVP compared to healthy controls?
Isolated hypertension is associated with early structural and functional markers of atherosclerosis, which can be assessed noninvasively using CIMT, FMD, and AVP.
Supports noninvasive vascular assessment in hypertension; leaves open prognostic value and therapeutic response in prospective studies.
BACKGROUND: Endothelial dysfunction is considered the first stage in the development of atherosclerosis. Brachial artery flow-mediated dilatation (FMD) has been used to assess endothelial dysfunction. An impaired FMD response may reflect a vascular phenotype prone to atherosclerosis. The thickness of the common carotid intima-media (CIMT) as measured by ultrasound represents a marker of structural atherosclerosis. Recently, it has been shown that color M-mode propagation velocity measured along the origin of descending thoracic aorta (AVP) may reflect atherosclerosis. In this study, the effects of isolated hypertension on these atherosclerosis markers are investigated. METHODS: Fifty patients with newly diagnosed hypertension and forty healthy people were enrolled. Patients were evaluated with transthoracic echocardiography. Diastolic functions were evaluated by transmitral filling parameters of deceleration time (DT), E/A ratio, and isovolumetric relaxation time (IVRT). Carotid intima-media thickness, FMD, and AVP were measured. RESULTS: Age, gender, and BMI of both groups were similar. Compared to control group CIMT, DT and IVRT values were significantly higher, and FMD and AVP values were significantly lower in hypertensive patients. There were significant correlations between AVP and CIMT (r =-0.699, P < 0.001), AVP and FMD (r = 0.400, P < 0.001), and FMD and CIMT (r =-0.600, P < 0.001). Carotid intima-media thickness, AVP, and FMD were significantly correlated with systolic and diastolic blood pressures and DT and IVRT. CONCLUSIONS: In patients with isolated hypertension, AVP and FMD decrease and CIMT increases. In addition, CIMT is inversely correlated with AVP and FMD, and AVP is directly correlated with FMD.
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Güntekin et al. (2009) conducted a case-control in Isolated hypertension (n=90). Isolated hypertension vs. Healthy controls was evaluated on Carotid intima-media thickness (CIMT), flow-mediated dilatation (FMD), and aortic propagation velocity (AVP). Isolated hypertension is associated with decreased AVP and FMD and increased CIMT compared to healthy controls, with AVP and CIMT showing a significant inverse correlation (r=-0.699, P<0.001).
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