Key result
Higher aortic velocity propagation is linked to ~2% lower odds of CAD.
Why the study?
Noninvasive imaging modalities to measure and monitor atherosclerosis, including color M-mode propagation velocity of descending aorta (AVP), require evaluation for correlation with coronary and carotid atherosclerosis and endothelial function.
Cross-Sectional (n=250)
No
Odds Ratio: 0.98 (95% CI 0.91–1)
p-value: p=0.001
AVP may aid noninvasive CAD detection; leaves open its incremental value beyond CIMT/FMD in prospective studies.
BACKGROUND: To improve clinical outcomes, noninvasive imaging modalities have been proposed to measure and monitor atherosclerosis. Common carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilatation (FMD) have correlated with coronary atherosclerosis. Recently, the color M-mode-derived propagation velocity of descending thoracic aorta (AVP) was shown to be associated with coronary artery disease (CAD). METHODS: CIMT, FMD, and AVP were measured in 92 patients with CAD and 70 patients having normal coronary arteries (NCA) detected by coronary angiography. Patients with acute myocardial infarction, renal failure or hepatic failure, aneurysm of aorta, severe valvular heart disease, left ventricular ejection fraction <40%, atrial fibrillation, frequent premature beats, left bundle branch block, and inadequate echocardiographic image quality were excluded. RESULTS: Compared to patients with normal coronary arteries, patients having CAD had significantly lower AVP (29.9 +/- 8.1 vs. 47.5 +/- 16.8 cm/sec, P < 0.001) and FMD (5.3 +/- 1.9 vs. 11.4 +/- 5.8%, P < 0.001) and higher CIMT (0.94 +/- 0.05 vs. 0.83 +/- 0.14 mm, P < 0.001) measurements. There were significant correlations between AVP and CIMT (r =-0.691, P < 0.001), AVP and FMD (r = 0.514, P < 0.001) and FMD and CIMT (r =-0.530, P < 0.001). CONCLUSIONS: The transthoracic echocardiographic determination of the color M-mode propagation velocity of the descending aorta is a simple practical method and correlates well with the presence of carotid and coronary atherosclerosis and brachial endothelial function.
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Güneş et al. (2010) conducted a cross-sectional in Suspected coronary artery disease (n=250). Aortic velocity propagation (AVP) vs. Patients without significant coronary artery disease was evaluated on Presence of coronary artery disease (OR 0.980, 95% CI 0.91-1, p=0.001). Aortic velocity propagation was significantly lower in patients with coronary artery disease and served as a strong independent inverse predictor of its presence (OR 0.980).
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