Key result
Coronary flow reserve was significantly lower in patients with coronary artery disease compared to controls (1.75 vs 2.40) and correlated significantly with carotid intima-media thickness (r = -0.403).
Why the study?
Does transthoracic coronary flow reserve correlate with brachial artery flow-mediated dilation and carotid intima-media thickness in patients with coronary artery disease?
Population
95 subjects, comprising 50 asymptomatic patients with coronary artery disease and 45 control subjects.
Comparison
Measurement of coronary flow reserve using… vs Control subjects without coronary artery disease.
Design
Cross-sectional
Authors
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May support CFR as surrogate for atherosclerosis burden in CAD; leaves open incremental value over IMT in prospective validation.
Cross-Sectional (n=95)
No
Does transthoracic coronary flow reserve correlate with brachial artery flow-mediated dilation and carotid intima-media thickness in patients with coronary artery disease?
Absolute Event Rate: 1.75% vs 2.4%
p-value: p=<0.001
Transthoracic coronary flow reserve correlates with established noninvasive markers of atherosclerosis (FMD and IMT), supporting its potential use as a surrogate for coronary atherosclerosis.
Öz (2012) conducted a cross-sectional in Coronary artery disease (n=95). Coronary artery disease vs. Control subjects without structural heart disease was evaluated on Coronary flow reserve (CFR) (p=<0.001). Coronary flow reserve was significantly lower in patients with coronary artery disease compared to controls (1.75 vs 2.40) and correlated significantly with carotid intima-media thickness (r = -0.403).