Key result
Cardiovascular risk factors in patients without clinical atherosclerosis were associated with significantly impaired flow-mediated dilation, greater intima-media thickness, and lower coronary flow reserve.
Why the study?
Do non-invasive vascular measurements (FMD, IMT, CFR) correlate with cardiovascular risk factors and Framingham score in patients without clinical atherosclerosis?
Population
106 subjects without clinical atherosclerosis, mean age 59.2 years, 42% male. 91 had cardiovascular risk…
Design
Cross-sectional
Authors
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May signal early vascular changes from risk factors; leaves open whether markers predict events or respond to therapy.
Cross-Sectional (n=106)
No
Do non-invasive vascular measurements (FMD, IMT, CFR) correlate with cardiovascular risk factors and Framingham score in patients without clinical atherosclerosis?
Mean Difference: 7.9 (95% CI 6.1–9.8)
Absolute Event Rate: 3.7% vs 11.6%
p-value: p=0.000
In patients without clinical atherosclerosis, cardiovascular risk factors are associated with impaired endothelial function, reduced coronary flow reserve, and increased intima-media thickness, with IMT correlating best with the Framingham risk score.
Campuzano et al. (2006) conducted a cross-sectional in Without clinical atherosclerosis (n=106). Cardiovascular risk factors vs. No cardiovascular risk factors was evaluated on Flow-mediated dilation (FMD) (MD 7.9%, 95% CI 6.1-9.8, p=0.000). Cardiovascular risk factors in patients without clinical atherosclerosis were associated with significantly impaired flow-mediated dilation, greater intima-media thickness, and lower coronary flow reserve.
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