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January 1, 2002Japanese Heart JournalOpen Access

Patients with coronary atherosclerosis in one or more vessels with lesion >= 50% had significantly reduced FMD compared with those with angiographically normal coronary arteries, whereas carotid IMT increased significantly only in patients with advanced CAD (lesion >= 90%).

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Population

Patients with suspected coronary artery disease (CAD) who had undergone coronary angiography.

Design

Cross-sectional

Authors

TFTomoo FurumotoSFSatoshi FujiiNSNaotaka Saito

Discussion

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Overview

FMD may mark early coronary atherosclerosis; leaves open whether serial FMD or IMT improves risk stratification in prospective cohorts.

Structured PICO

P
Population
Patients with suspected coronary artery disease (CAD) who had undergone coronary angiography.
O
Outcome
Brachial artery flow mediated dilation (FMD) and carotid artery intima-media thickness (IMT)surrogate

Functional endothelial changes measured by brachial artery FMD occur in early stages of coronary artery disease, whereas structural changes measured by carotid IMT appear in more advanced disease.

Cite This Study

Furumoto et al. (2002) studied this question.

synapsesocial.com/papers/6a6f684ffebe604dd7085515https://doi.org/10.1536/jhj.43.117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship Between Brachial Artery Flow-Mediated Dilation, Carotid Artery Intima-Media Thickness and Coronary Flow Reserve in Patients With Coronary Artery Disease2012 · 8 citations
  2. 2Correlation Between Flow-Mediated Vasodilatation of the Brachial Artery and Intima-Media Thickness in the Carotid Artery in Men1999 · 144 citations
  3. 3Evidence of a weak correlation between peripheral endothelial function measures and carotid intima-media thickness2012
  4. 4Interrelations Between Brachial Endothelial Function and Carotid Intima-Media Thickness in Young Adults2004 · 424 citations
  5. 5The Relationship Between Flow‐Mediated Dilatation of the Brachial Artery and Intima‐Media Thickness of the Carotid Artery to Framingham Risk Scores in Older African Americans2009 · 13 citations