Key result
Arterial hypertension is linked to impaired endothelial function despite normal nitroglycerin-mediated dilatation.
Why the study?
The presence of abnormal endothelial function in patients with arterial hypertension was evaluated to understand vascular impairment.
Is abnormal endothelial function present in patients with arterial hypertension?
Observational
Is abnormal endothelial function present in patients with arterial hypertension?
Patients with arterial hypertension demonstrate impaired endothelium-dependent vasodilation but preserved endothelium-independent vasodilation.
Impaired FMD with preserved NMD in hypertension supports selective endothelial dysfunction; leaves open causal role and need for prospective trials.
The aim of our study was to evaluate whether abnormal endothelial function is present in patients with arterial hypertension. Endothelial function was assessed by measuring flow-mediated dilatation (FMD) and nitroglycerin-mediated dilatation of the brachial artery using high-resolution ultrasound. In the group of subjects with arterial hypertension endothelial function was significantly impaired (FMD 9,26%), whereas nitroglycerin-mediated dilatation was normal.
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Шишкин et al. (2008) conducted an observational in Arterial hypertension. Arterial hypertension was evaluated on Endothelial function assessed by flow-mediated dilatation (FMD). Arterial hypertension was associated with significantly impaired endothelial function (FMD 9.26%), whereas nitroglycerin-mediated dilatation remained normal.
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