January 1, 2000British Journal of PharmacologyOpen Access

Nitric oxide, prostanoid and non‐NO, non‐prostanoid involvement in acetylcholine relaxation of isolated human small arteries

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Population

Isolated human subcutaneous small arteries

Design

Preclinical

Authors

NBNiels Henrik BuusGeneral / Preventive / Lipids USUlf SimonsenAarhus University MMMichael J. MulvanyVascular / Pulmonary Vascular

Discussion

Member takes

Implication

EDH may predominate in small artery relaxation; leaves open human translation and therapeutic relevance.

Structured PICO

Population

Isolated human subcutaneous small arteries

Intervention

Acetylcholine (ACh) with and without various pathway inhibitors (L-NOARG, indomethacin, ODQ, etc.)

Outcome

Isometric tension (relaxation), NO concentration, and smooth muscle membrane potentialsurrogate

In human subcutaneous small arteries, acetylcholine-induced relaxation is primarily driven by endothelium-dependent hyperpolarization rather than nitric oxide or prostanoids.

Cite This Study

Buus et al. (2000) studied this question.

synapsesocial.com/papers/6a7cf33059efdf8f26394514 https://doi.org/10.1038/sj.bjp.0703041

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Ask AI

Bookmark

Nitric oxide, prostanoid and non‐NO, non‐prostanoid involvement in acetylcholine relaxation of isolated human small arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide, prostanoid and non‐NO, non‐prostanoid involvement in acetylcholine relaxation of isolated human small arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider