August 1, 1988Canadian Journal of Physiology and Pharmacology

Inhibition of cardiac slow action potentials by 8-bromo-cyclic GMP occurs independent of changes in cyclic AMP levels

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Structured PICO

Population

Guinea pig papillary muscles

Intervention

Superfusion with 8-bromo-cyclic GMP (10(-3) M)

Comparator

Superfusion with isoproterenol (10(-6) M), forskolin (10(-6) M), or histamine (10(-6) M) alone

Outcome

Cyclic AMP levels and Ca-dependent slow action potentialssurrogate

The inhibitory effect of cyclic GMP on slow Ca channels in guinea pig ventricular cells is independent of cyclic AMP levels, suggesting a cyclic GMP-mediated phosphorylation mechanism.

Discussion

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Implication

cGMP inhibition of Ca channels appears cAMP-independent in guinea pig ventricle; leaves open relevance to human electrophysiology.

Cite This Study

Thakkar et al. (1988) studied this question.

synapsesocial.com/papers/6a91a7c3eb7f1f9a6abe483f https://doi.org/10.1139/y88-178

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Inhibition of cardiac slow action potentials by 8-bromo-cyclic GMP occurs independent of changes in cyclic AMP levels

Structured PICO

Discussion

Implication

Cite This Study

Inhibition of cardiac slow action potentials by 8-bromo-cyclic GMP occurs independent of changes in cyclic AMP levels

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider