Population
Guinea pig papillary muscle cells depolarized to about -45 mV by superfusion with 22 mM K+-Tyrode's solution…
Comparison
Intracellular pressure injections of cAMP, Gppp… vs Intracellular injection of 5'-AMP; superfusion…
Design
Preclinical
Authors
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Should not change clinical practice; leaves open mechanistic extension to intact hearts or arrhythmia models.
Intracellular injection of cAMP and adenylate cyclase activators rapidly induces slow action potentials in guinea pig papillary muscle cells, supporting a causal role for cAMP in cardiac slow channel function.
Li et al. (1983) studied this question.
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