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June 1, 1985British Journal of PharmacologyOpen Access

Stimulation rate modulates effects of the dihydropyridine CGP 28 392 on cardiac calcium‐dependent action potentials

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Population

guinea-pig papillary muscle depolarized with 22 mM potassium (K+)

Comparison

CGP 28 392 at various pacing frequencies vs absence of CGP 28 392

Design

Preclinical

Authors

TKTimothy J. KampElectrophysiologyRMRichard J. MillerNorthwestern UniversityMSMichael C. SanguinettiElectrophysiology

Discussion

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Implication

Hypothesis-generating for rate-selective Ca2+ modulation; leaves open relevance to intact mammalian or human physiology.

Structured PICO

P
Population
guinea-pig papillary muscle depolarized with 22 mM potassium (K+)
I
Intervention
CGP 28 392 (10 microM) at various pacing frequencies
C
Comparator
absence of CGP 28 392
O
Outcome
maximum upstroke velocity (Vmax) of the slow response action potentialsurrogate

CGP 28 392 acts as a partial Ca2+-channel agonist whose effects on cardiac calcium current are voltage-dependent and modulated by stimulation rate.

Cite This Study

Kamp et al. (1985) studied this question.

synapsesocial.com/papers/6a8a824981f71cbdf7de85dfhttps://doi.org/10.1111/j.1476-5381.1985.tb08889.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Papaverine and Verapamil on Frequency-Dependent Changes in &OV0312;max of K-Depolarized Ventricular Tissue1982 · 9 citations
  2. 2Calcium Channel Modulation1984 · 129 citations
  3. 3Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.1983 · 55 citations
  4. 4Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.1984 · 322 citations
  5. 5Effects of Bay k 8644, a dihydropyridine analog, on [3H]nitrendipine binding to canine cardiac sarcolemma and the relationship to a positive inotropic effect.1984 · 37 citations