Key result
Increasing stimulation rate reduced basal L-type Ca2+ current, an effect that was greatly enhanced by elevating cAMP levels through Ca2+-dependent phosphodiesterase activation.
Population
Single ventricular cardiomyocytes isolated from guinea pig hearts
Comparison
Changes in stimulation frequency combined with… vs Basal state
Design
Preclinical
Authors
Loading...
May inform rate-dependent Ca2+ regulation in ventricular myocytes; leaves open translation to human physiology and disease.
In guinea pig ventricular cardiomyocytes, Ca2+ entry causes feedback regulation of L-type Ca2+ current via Ca2+-dependent phosphodiesterases, a mechanism relevant during sympathetic stimulation.
Kaspar et al. (1995) studied this question. Changes in stimulation frequency and cAMP-elevating drugs vs. Basal state was evaluated on Modulation of L-type Ca2+ current (ICa). Increasing stimulation rate reduced basal L-type Ca2+ current, an effect that was greatly enhanced by elevating cAMP levels through Ca2+-dependent phosphodiesterase activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: