Population
Guinea-pig single ventricular cells
Design
Preclinical
Authors
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Refines beta-adrenergic IK modulation in ventricular myocytes; extends cAMP-PKA pathway data in animals but leaves human translation open.
Beta-adrenergic modulation of the delayed outward potassium current in guinea-pig ventricular myocytes is mediated by cyclic AMP-dependent phosphorylation, with independent enhancement by PKA and PKC.
Yazawa et al. (1990) studied this question.
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