Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1992Experimental PhysiologyOpen Access

Rate dependence of action potential duration and calcium current in isolated guinea‐pig cardiocytes

View Full Paper
Ask AI
Bookmark
Share

Key result

Increasing the pacing rate from 0.28 to 0.75 Hz induced a transient increase in APD50 (6.8 +/- 2.9%) and facilitated peak calcium currents in isolated guinea-pig ventricular cells.

Population

Single cardiac guinea-pig ventricular cells

Comparison

Pacing rate changes and intracellular calcium… vs Rest period or baseline pacing rate without…

Design

Preclinical

Authors

NPNicolas PeineauUniversité de ToursDGD GarnierUniversité de ToursAJArgibay JaLaboratoire de Mathématiques et Physique Théorique

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for rate-dependent calcium effects in myocytes; leaves open translation to human arrhythmia management.

Structured PICO

P
Population
Isolated guinea-pig ventricular cells studied using whole-cell patch-clamp techniques.
I
Intervention
Pacing rate changes (0.28 Hz to 0.75 Hz) and intracellular calcium buffering (EGTA or BAPTA)
C
Comparator
Rest period or baseline pacing rate (0.28 Hz) without intracellular calcium buffer
O
Outcome
Action potential duration at 50% of its amplitude (APD50) and peak calcium currents (ICa)surrogate

In isolated guinea-pig ventricular cells, increases in pacing rate induce transient increases in action potential duration that appear dependent on calcium entry via calcium channels.

Cite This Study

Peineau et al. (1992) studied this question. Increased pacing rate vs. Baseline pacing (0.28 Hz) was evaluated on Action potential duration at 50% amplitude (APD50) and peak calcium currents (ICa). Increasing the pacing rate from 0.28 to 0.75 Hz induced a transient increase in APD50 (6.8 +/- 2.9%) and facilitated peak calcium currents in isolated guinea-pig ventricular cells.

synapsesocial.com/papers/6a20326aeab213b7bb295073https://doi.org/10.1113/expphysiol.1992.sp003624
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium-sensitive delayed rectifier potassium current in guinea pig ventricular cells1990 · 149 citations
  2. 2Intracellular Ca2+ and protein kinase C modulate K+ current in guinea pig heart cells1987 · 138 citations
  3. 3Stimulation‐dependent facilitation of the high threshold calcium current in guinea‐pig ventricular myocytes.1990 · 92 citations
  4. 4Two types of calcium channels in guinea pig ventricular myocytes.1986 · 232 citations
  5. 5Potentiation of the calcium-channel currents of internally perfused mammalian heart cells by repetitive depolarization.1987 · 112 citations