Population
Guinea pig ventricular myocytes
Comparison
Action potential clamp protocol simulating a… vs Square pulse voltage-clamp protocol
Design
Preclinical
Authors
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AP clamp offers a physiological approach to ICa in animal cardiomyocytes; leaves open translation to human excitation-contraction coupling.
The AP clamp protocol reveals that transsarcolemmal Ca2+ influx during a physiological action potential has a complex time course involving both L- and T-type channels, providing a more physiological approach to studying excitation-contraction coupling.
Arreola et al. (1991) studied this question.
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