Population
Isolated guinea-pig ventricular myocytes
Comparison
Manipulation of internal Ca2+ homeostasis using… vs Unmanipulated internal Ca2+ homeostasis
Design
Preclinical
Authors
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Requires human validation before informing arrhythmia therapies; extends mechanistic insight into Ca2+-dependent inactivation in animal models.
L-type calcium channel inactivation during the cardiac action potential is primarily driven by calcium entry through the channels themselves, with early contribution from sarcoplasmic reticulum calcium release.
Linz et al. (1998) studied this question.
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