Key result
Inactivation of non-specific current through calcium channels is due solely to an intrinsic voltage-dependent process, accounting for significant inactivation at negative and positive potentials.
Population
Single guinea-pig ventricular myocytes
Design
Preclinical
Authors
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Voltage-dependent Ca-channel inactivation in guinea-pig myocytes remains hypothesis-generating; leaves open translation to human physiology and clinical relevance.
Demonstrates an intrinsic voltage-dependent inactivation mechanism for calcium channels in guinea-pig ventricular myocytes.
Hadley et al. (1987) studied this question. Voltage-dependent inactivation protocols was evaluated on Inactivation of the Ca2+ current (ICa) and non-specific current (Ins). Inactivation of non-specific current through calcium channels is due solely to an intrinsic voltage-dependent process, accounting for significant inactivation at negative and positive potentials.