What does this research mean for the field?

In ventricular myocytes, the transition of sodium channels directly from resting to inactivated states is steeply voltage-dependent, causing significant inactivation at diastolic potentials, whereas inactivation above the action potential threshold occurs primarily from the open state. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1991The Journal of PhysiologyOpen Access

Sodium channel inactivation from resting states in guinea‐pig ventricular myocytes.

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Population

Isolated guinea-pig ventricular myocytes

Design

Preclinical

Authors

JLJohn H. LawrenceSouthern Illinois University Carbondale DYDavid T. YueJohns Hopkins University WRWilliam C. RoseThe Wistar Institute

Discussion

Member takes

Implication

May affect ventricular excitability at diastolic potentials in this model; leaves open translation to human arrhythmia mechanisms.

Structured PICO

Population

Isolated guinea-pig ventricular myocytes

Intervention

Cell-attached patch-clamp technique with high [Na+] in the pipette and varying membrane potentials

Outcome

Probability that the sodium channel enters the inactivated state directly from resting states (C->I)surrogate

In guinea-pig ventricular myocytes, sodium channel inactivation from resting states is highly voltage-dependent and may cause significant inactivation at diastolic potentials.

Cite This Study

Lawrence et al. (1991) studied this question.

synapsesocial.com/papers/6a193cd6fa25ab5db6d944f7 https://doi.org/10.1113/jphysiol.1991.sp018855

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Ask AI

Bookmark

Sodium channel inactivation from resting states in guinea‐pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sodium channel inactivation from resting states in guinea‐pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider