June 1, 1989The Journal of PhysiologyOpen Access

Properties of calcium channels in guinea‐pig gastric myocytes.

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Population

Enzymatically dispersed guinea-pig gastric myocytes

Comparison

Whole-cell voltage clamp technique with various… vs Control conditions

Design

Preclinical

Authors

DKDavid A. KatzkaColumbia University Irving Medical Center MMMartin MoradElectrophysiology

Discussion

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Implication

Characterizes Ca2+ currents in gastric myocytes; leaves open translation to human physiology or therapy.

Structured PICO

Population

Enzymatically dispersed guinea-pig gastric myocytes

Intervention

Whole-cell voltage clamp technique with various ion substitutions (Ba2+ for Ca2+), buffering systems (EGTA, EDTA, citrate), pH changes, and calcium channel blockers (nifedipine, D600, diltiazem)

Comparator

Control conditions (e.g., Ca2+ as charge carrier, standard pH, absence of blockers)

Outcome

Properties of the inward membrane Ca2+ current (activation threshold, inactivation kinetics, divalent selectivity, and pharmacological inhibition)surrogate

This preclinical study characterizes the electrophysiological and pharmacological properties of calcium channels in guinea-pig gastric myocytes.

Cite This Study

Katzka et al. (1989) studied this question.

synapsesocial.com/papers/6a83874546c7ded554a77f8a https://doi.org/10.1113/jphysiol.1989.sp017648

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Properties of calcium channels in guinea‐pig gastric myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Properties of calcium channels in guinea‐pig gastric myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider