Population
Isolated guinea pig ventricular myocytes
Design
Preclinical
Authors
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Warrants caution interpreting Ca tail currents in myocyte studies; leaves open voltage sensor-independent inactivation mechanisms for further preclinical investigation.
This preclinical study demonstrates that charge movement in guinea pig ventricular myocytes is dominated by L-type Ca channel gating current, suggesting Ca channels can be inactivated by means that do not affect the voltage sensor.
Hadley et al. (1991) studied this question.
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