February 1, 2003AJP Heart and Circulatory Physiology

Is there an A-type K+ current in guinea pig ventricular myocytes?

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Population

guinea pig ventricular myocytes

Design

Preclinical

Authors

IFIan FindlayUniversité de Tours

Discussion

Member takes

Implication

Reattributes Ca2+-free outward current to L-type channel K+ efflux in guinea pig myocytes; leaves open whether A-type K+ masking occurs in other species or humans.

Structured PICO

Population

guinea pig ventricular myocytes

Intervention

removal of extracellular Ca(2+) and application of ion channel inhibitors (Cd(2+), Ni(2+), Co(2+), La(3+), nifedipine, 4-aminopyridine)

Outcome

Determination of whether the transient outward current represents K(+)-selective I(to) or K(+) efflux via L-type Ca(2+) channelssurrogate

The transient outward current observed upon removal of extracellular Ca(2+) in guinea pig ventricular myocytes is due to K(+) efflux through L-type Ca(2+) channels, not a distinct A-type K(+) current.

Cite This Study

Ian Findlay (2003) studied this question.

synapsesocial.com/papers/6a7085992163a0a01bc4bcdb https://doi.org/10.1152/ajpheart.00687.2002

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Implication

Reattributes Ca2+-free outward current to L-type channel K+ efflux in guinea pig myocytes; leaves open whether A-type K+ masking occurs in other species or humans.

Is there an A-type K+ current in guinea pig ventricular myocytes?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Is there an A-type K+ current in guinea pig ventricular myocytes?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider