Population
Guinea pig cardiac cells
Comparison
Removal of extracellular Ca2+ and application of… vs Physiological concentrations of extracellular Ca2+
Design
Preclinical
Authors
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Physiological Ca2+ masking of A-type K+ channels in guinea pig cells should not change practice; leaves open their functional relevance in human cardiac electrophysiology.
Extracellular Ca2+ at physiological concentrations masks the activity of an A-type K+ channel in guinea pig cardiac cells, implying that genetically identified channels may not necessarily function under physiological conditions.
Inoue et al. (1993) studied this question.
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