June 1, 1992The Journal of General PhysiologyOpen Access

Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes.

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Population

Guinea pig ventricular myocytes

Design

Preclinical

Authors

RSRoman ShirokovRutgers, The State University of New Jersey RLRichard A. LevisRush University Medical Center NSNatalia ShirokovaResearch Centre for Medical Genetics

Discussion

Member takes

Implication

Extends skeletal muscle charge concepts to cardiac L-type channels in guinea pig myocytes; leaves open human relevance and therapeutic implications.

Structured PICO

Population

Guinea pig ventricular myocytes

Intervention

Whole-cell patch clamp technique with voltage protocols and 100 microns D600

Outcome

Intramembrane charge movement (gating currents), voltage dependence, and kineticssurrogate

Identified two classes of gating currents from L-type calcium channels in guinea pig ventricular myocytes, providing fundamental electrophysiological insights.

Cite This Study

Shirokov et al. (1992) studied this question.

synapsesocial.com/papers/6a733f5064decaab472c2220 https://doi.org/10.1085/jgp.99.6.863

View Full Paper

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Implication

Extends skeletal muscle charge concepts to cardiac L-type channels in guinea pig myocytes; leaves open human relevance and therapeutic implications.

Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider