Population
Guinea-pig heart cells (ventricular myocytes)
Design
Preclinical
Authors
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Findings from guinea-pig myocytes warrant caution before clinical translation; leaves open validation in human ventricular electrophysiology.
The study characterizes the macroscopic and unitary properties of L-type Ca2+ channels in guinea-pig ventricular myocytes, revealing that the maintained current component is largely due to an 'active-late' gating pattern lacking an inactivated state.
Rose et al. (1992) studied this question.
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