Kinetic properties of the cardiac T‐type calcium channel in the guinea‐pig.
Population
Single ventricular cells from guinea-pig hearts (139 patches)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No clinical implications from guinea-pig data; extends T-type Ca2+ channel characterization but leaves open human relevance.
Structured PICO
P
Population
Single ventricular cells from guinea-pig hearts (139 patches)
I
Intervention
Cell-attached configuration of the patch-clamp technique
O
Outcome
Kinetic properties of T-type Ca2+ channels (density, conductance, activation/inactivation, open/closed times)surrogate
This study characterizes the kinetic properties, including subconductance states and voltage-dependent kinetics, of T-type calcium channels in guinea-pig ventricular cells.
Cite This Study
Droogmans et al. (1989) studied this question.