Key result
Isolated guinea pig ventricular myocytes possess two distinct types of Ca2+ channels with different activation thresholds, inactivation kinetics, and pharmacological sensitivities.
Population
Isolated guinea pig ventricular myocytes
Design
Preclinical
Authors
Loading...
May support dual Ca2+ channels in guinea pig myocytes; leaves open human relevance and should not yet change practice.
Provides foundational evidence for the existence of two distinct types of calcium channels in cardiac ventricular muscle.
Mitra et al. (1986) studied this question. Isolated guinea pig ventricular myocytes possess two distinct types of Ca2+ channels with different activation thresholds, inactivation kinetics, and pharmacological sensitivities.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: