November 1, 1992The Journal of PhysiologyOpen Access

Ca2+ currents in single myocytes from human mesenteric arteries: evidence for a physiological role of L‐type channels.

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Population

Isolated human mesenteric arterial cells (single myocytes), n=33 cells.

Comparison

Exposure to solutions containing elevated Ca2+… vs Normal (1.5 mM) Ca2+ solution.

Design

Preclinical

Authors

SSSmirnov SvRutgers, The State University of New Jersey PAPhilip I. AaronsonKing's College London

Discussion

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Implication

Human mesenteric myocyte data require in vivo validation; leaves open T-type channel roles in mesenteric tone.

Structured PICO

Population

Isolated human mesenteric arterial cells (single myocytes), n=33 cells.

Intervention

Exposure to solutions containing elevated (20 mM) Ca2+ or 10 mM Ba2+ during whole-cell patch clamp.

Comparator

Normal (1.5 mM) Ca2+ solution.

Outcome

Characterization of voltage-gated Ca2+ currents (ICa), specifically T- and L-type currents.surrogate

Isolated human mesenteric arterial myocytes possess both T- and L-type voltage-gated calcium channels, with L-type channels exhibiting calcium-dependent inactivation.

Cite This Study

Sv et al. (1992) studied this question.

synapsesocial.com/papers/6a6f86378031ec7bb1dbccdf https://doi.org/10.1113/jphysiol.1992.sp019387

View Full Paper

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Ca2+ currents in single myocytes from human mesenteric arteries: evidence for a physiological role of L‐type channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ca2+ currents in single myocytes from human mesenteric arteries: evidence for a physiological role of L‐type channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider