November 1, 2017Open Access

Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles

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Population

Smooth muscle cells of 4th order arterioles in mouse skeletal muscle

Design

Preclinical

Authors

AUAlexandra V. UlyanovaPhiladelphia VA Medical Center RSRoman ShirokovRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Hypothesis-generating for arteriole ion channel regulation in animals; leaves open translation to human vascular function.

Structured PICO

Population

Smooth muscle cells of 4th order arterioles in mouse skeletal muscle

Intervention

Application of channel blockers (nifedipine 10 μM, tetrodotoxin 1 μM) and modulators (caffeine 10 mM, isobutylmethylxanthine 1 mM) under varying calcium concentrations

Outcome

Voltage-dependent inward currents responsible for the depolarizing phase of action potentialssurrogate

Voltage-gated Na+ channels, alongside T- and L-type Ca2+ channels, play a role in the depolarization of skeletal muscle arteriole smooth muscle cells and are tightly regulated by Ca2+ signaling.

Cite This Study

Ulyanova et al. (2017) studied this question.

synapsesocial.com/papers/6a7d7cea2c1f7923a796606b https://doi.org/10.1101/211540

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Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider