Key result
Nifedipine reduces inward current at positive potentials in dual-threshold rabbit smooth muscle calcium channels.
Population
Single smooth muscle cells of rabbit ear artery
Design
Preclinical
Authors
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Caution against assuming uniform nifedipine effects across potentials in vivo; extends evidence for distinct low- and high-threshold channels in smooth muscle.
This preclinical study characterizes the voltage-dependent calcium channels in smooth muscle cells and their complex response to nifedipine based on membrane potential.
Bolton et al. (1988) studied this question. Voltage clamp and Nifedipine was evaluated on Calcium channel inward current characteristics. In single smooth muscle cells of rabbit ear artery, voltage-dependent calcium channels exhibit low- and high-threshold components, with nifedipine reducing inward current at positive potentials.
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