November 1, 1992The Journal of PhysiologyOpen Access

Ca(2+)‐activated and voltage‐gated K+ currents in smooth muscle cells isolated from human mesenteric arteries.

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Population

Smooth muscle cells enzymatically isolated from arteries dissected from mesenteric fat removed from patients…

Design

Preclinical

Authors

SSSmirnov SvRutgers, The State University of New Jersey PAPhilip I. AaronsonKing's College London

Discussion

Member takes

Implication

No immediate clinical implications; extends human mesenteric VSMC electrophysiology data but leaves therapeutic translation open.

Structured PICO

Population

Smooth muscle cells enzymatically isolated from arteries dissected from mesenteric fat removed from patients undergoing routine surgery.

Intervention

Whole-cell patch clamp technique using high-K+ pipette solutions with varying EGTA/BAPTA concentrations and application of pharmacological agents (TEA, charybdotoxin, caffeine, 4-AP, Cd2+).

Outcome

Characterization of potassium (K+) currents and passive electrical properties.surrogate

This basic science study characterizes the distinct Ca2+-activated and voltage-gated potassium currents present in human mesenteric artery smooth muscle cells.

Cite This Study

Sv et al. (1992) studied this question.

synapsesocial.com/papers/6a82c564d88fdfcf4fa0cb91 https://doi.org/10.1113/jphysiol.1992.sp019386

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November 1, 1992The Journal of PhysiologyOpen Access

Ca(2+)‐activated and voltage‐gated K+ currents in smooth muscle cells isolated from human mesenteric arteries.

View Full Paper

Ask AI

Bookmark

Population

Smooth muscle cells enzymatically isolated from arteries dissected from mesenteric fat removed from patients…

Design

Preclinical

Authors

SSSmirnov SvRutgers, The State University of New Jersey PAPhilip I. AaronsonKing's College London

Discussion

Member takes

Implication

No immediate clinical implications; extends human mesenteric VSMC electrophysiology data but leaves therapeutic translation open.

Structured PICO

Population

Smooth muscle cells enzymatically isolated from arteries dissected from mesenteric fat removed from patients undergoing routine surgery.

Intervention

Whole-cell patch clamp technique using high-K+ pipette solutions with varying EGTA/BAPTA concentrations and application of pharmacological agents (TEA, charybdotoxin, caffeine, 4-AP, Cd2+).

Outcome

Characterization of potassium (K+) currents and passive electrical properties.surrogate

This basic science study characterizes the distinct Ca2+-activated and voltage-gated potassium currents present in human mesenteric artery smooth muscle cells.

Cite This Study

Sv et al. (1992) studied this question.

synapsesocial.com/papers/6a82c564d88fdfcf4fa0cb91 https://doi.org/10.1113/jphysiol.1992.sp019386

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