June 1, 1992The Journal of PhysiologyOpen Access

Characterization of membrane currents in single smooth muscle cells from the guinea‐pig gastric antrum.

View Full Paper

Ask AI

Bookmark

Population

Single smooth muscle cells enzymatically isolated from the antrum of the guinea-pig stomach

Design

Preclinical

Authors

TNThomas NoackUniversity of Bern PDPetra DeitmerPhilipps University of Marburg ELE. LammelConsejo Nacional de Investigaciones Científicas y Técnicas

Discussion

Member takes

Implication

Characterizes antral myocyte currents in detail; leaves open translation to human GI or cardiovascular physiology.

Structured PICO

Population

Single smooth muscle cells enzymatically isolated from the antrum of the guinea-pig stomach

Intervention

Voltage clamp using whole-cell patch clamp technique in physiological salt solution (PSS) with various pharmacological agents (4-AP, TEA, caffeine, Cd2+)

Outcome

Characterization of inward calcium current and outward potassium currents (Ca2+-dependent and independent components)surrogate

This study characterizes the distinct calcium and potassium membrane currents in guinea-pig gastric antrum smooth muscle cells, detailing their voltage dependence and pharmacological sensitivities.

Cite This Study

Noack et al. (1992) studied this question.

synapsesocial.com/papers/6a85380fca39fc72e8c2a5b1 https://doi.org/10.1113/jphysiol.1992.sp019170

View Full Paper

Ask AI

Bookmark

Characterization of membrane currents in single smooth muscle cells from the guinea‐pig gastric antrum.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of membrane currents in single smooth muscle cells from the guinea‐pig gastric antrum.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider